6 May 2008 Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors
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Abstract
A new integrated lensless bio-photonic sensors is being developed. It replaces the ordinary slide supporting the DNA spots, and the complex, large and expensive hybridisation and the scanner reading system, by a sandwich of well defined chemical and optical layers grafted onto a CCD sensor. The upper layer of the new biochip performs the biological function. Due to the architecture of the biochip leading to a lensless imaging of the spots directly on the sensor pixels, the images produced will have novel characteristics beyond the analysis capacity of reading software packages of microarray analysis. In this framework, specific image processing and statistical data analysis algorithms have been developed in order to assess and to quantify these images.
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Jesús Angulo, Jesús Angulo, Christian Lajaunie, Christian Lajaunie, Michel Bilodeau, Michel Bilodeau, Lucio Martinelli, Lucio Martinelli, Françoise Le Boulaire, Françoise Le Boulaire, Fernand Meyer, Fernand Meyer, } "Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors", Proc. SPIE 7000, Optical and Digital Image Processing, 700014 (6 May 2008); doi: 10.1117/12.781377; https://doi.org/10.1117/12.781377
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