5 June 2008 New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester
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Proceedings Volume 7022, Advanced Laser Technologies 2007; 702204 (2008); doi: 10.1117/12.803904
Event: Advanced Laser Technologies 2007, 2007, Levi, Finland
Abstract
This work is devoted to investigation of new photosensitizer Bacteriochlorin p N-methoxycycloimide oxyme methyl ester (BchlpOx-NOMe). Investigations of photosensitizer in vivo and experimental PDT were performed on animals bearing intramuscularly inoculated Erlich tumor and B16 melanoma. Characteristic absorption maximum of BchlpOx-NOMe around 795 nm is within the range of minimum intrinsic absorption of biological tissue. Dynamics and selectivity of sensitizer accumulation in tumor and normal tissue were estimated from spectra of absorption of sensitized tissue in vivo. The investigation has shown that the optimum time range to start PDT irradiation of tumor is 10-30 min after administration. Photosensitizer has shown high photodynamic efficiency of relatively large tumors, including high PDT efficiency in preliminary experiments with BDF1 mice bearing B16 melanoma, causing tumor growth inhibition more than 90% and prolongation of lifespan of tumor-bearing animals more than 60%.
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Igor G. Meerovich, Mikhail A. Grin, Alexander G. Tsyprovskiy, Gennady A. Meerovich, Natalia A. Oborotova, Victor B. Loschenov, Anatoly Yu. Baryshnikov, Andrey F. Mironov, "New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester", Proc. SPIE 7022, Advanced Laser Technologies 2007, 702204 (5 June 2008); doi: 10.1117/12.803904; https://doi.org/10.1117/12.803904
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KEYWORDS
Tumors

Photodynamic therapy

Absorption

Melanoma

Tissues

In vivo imaging

Tissue optics

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