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5 June 2008 Frequency spectrum analysis of pulsed photoacoustic signals in Intralipid
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Proceedings Volume 7022, Advanced Laser Technologies 2007; 702215 (2008)
Event: Advanced Laser Technologies 2007, 2007, Levi, Finland
The basic aim of this study was to analyze the frequency spectrum of photoacoustic signals generated in Intralipid and water. Intralipid, which is a well-known tissue simulating phantom, was used with concentrations of 1 % and 2 %. Some of the experiments involved the addition of glucose (5000 mg/dl). Measurement results demonstrated that, at 1064 nm, the intensity of the obtained spectra is higher in water than in Intralipid. Also the shapes of the acoustic spectra measured for water and Intralipid were dissimilar. The relative part of low-frequency components was found to be larger in Intralipid than in water. On the other hand, a clear intensity maximum was found in the frequency spectrum of water, whereas in Intralipid, intensity decreased towards higher frequencies from a maximum of less than 0.5 MHz. Moreover, water had a wider and smoother photoacoustic signal spectrum. 1 % and 2 % Intralipid concentrations differed mainly in terms of acoustic wave amplitude, while glucose had a negligible effect on the acoustic spectra of these solutions. The calculated spectral moments, namely, variance of the power spectrum, skewness and kurtosis, were no better indicators for glucose than the peak-to-peak value.
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Matti Kinnunen and Risto Myllylä "Frequency spectrum analysis of pulsed photoacoustic signals in Intralipid", Proc. SPIE 7022, Advanced Laser Technologies 2007, 702215 (5 June 2008);

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