26 August 2008 Nanophotonics bio-sensor using gold nanostructure
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As a bio-molecular-sensor with high sensitivity using surface-enhanced Raman scattering (SERS), we developed two dimensional gold nano-mushroom arrays (G-NAMS). Because the heads of the gold mushrooms are closely placed over all aspects on a surface of substrate, a lot of SERS enable spot, so called "hot spots", are formed. . By using G-NAMS, we observed Raman signals of some bio samples. In the experiment to observe the adenine, which is one of four basis of the gene, dissolved in PBS solution, adenine concentrations of 5 pM could be detected. FDTD simulation indicated, that strong Raman enhancement of G-NAMS occurs due to synergistic action of the hot spots produced between metal nanoparticles, and the optical resonant effect in the alumina layer.
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Masayuki Naya, Masayuki Naya, Takeharu Tani, Takeharu Tani, Yuichi Tomaru, Yuichi Tomaru, Jingbo Li, Jingbo Li, Naoki Murakami, Naoki Murakami, "Nanophotonics bio-sensor using gold nanostructure", Proc. SPIE 7032, Plasmonics: Metallic Nanostructures and Their Optical Properties VI, 70321Q (26 August 2008); doi: 10.1117/12.800900; https://doi.org/10.1117/12.800900

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