29 August 2008 Noninvasive measurement of intracellular viscoelastic properties
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We are exploring a biological application of optical tweezers with fluorescence imaging for microrheometry. Measurement of the power spectrum of Brownian motion of a trapped probe particle or vesicle provides information on the viscoelastic properties of the surrounding medium which can change in response to cellular processes or the effect of drugs.
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Martha B. Alvarez-Elizondo, Martha B. Alvarez-Elizondo, Susan H. Roelofs, Susan H. Roelofs, Frederic A. Meunier, Frederic A. Meunier, Norman Heckenberg, Norman Heckenberg, Halina Rubinsztein-Dunlop, Halina Rubinsztein-Dunlop, } "Noninvasive measurement of intracellular viscoelastic properties", Proc. SPIE 7038, Optical Trapping and Optical Micromanipulation V, 70380D (29 August 2008); doi: 10.1117/12.793591; https://doi.org/10.1117/12.793591

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