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9 September 2008 Silica nanoparticle inline size measurement using refractive index gradient in a microfluidic cell
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Abstract
In this article, we report a technique that can measure the size of silica nanoparticles in a microfluidic Y-Cell. In this technique, silica nanoparticle dispersion and a buffer solution are pumped through a micro-fabricated microfluidic Y-Cell, in which these two solutions form laminar flows and nanoparticles diffuse into the buffer due to the concentration gradient. The diffusion of nanoparticles into buffer causes a refractive index gradient across the boundary between nanoparticle dispersion and buffer. The refractive index gradients at different positions of the boundary can be measured by optical method and this information is used to calculate the nanoparticle diffusion coefficient, which is then used to calculate the nanoparticle size. We have demonstrated this technique with 5nm and 20nm silica nanoparticles. This technique is relatively fast and easy to implement, and proves to be an ideal candidate for inline process monitoring applications where fast and qualitative measurement is desired.
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Yi Qiao, Dave Hofeldt, Brian Graebel, John Ramthun, and Michael Dolezal "Silica nanoparticle inline size measurement using refractive index gradient in a microfluidic cell", Proc. SPIE 7042, Instrumentation, Metrology, and Standards for Nanomanufacturing II, 70420J (9 September 2008); https://doi.org/10.1117/12.798766
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