2 September 2008 Fourier transform infrared spectroscopy of deuterated proteins
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Abstract
We report on Fourier transform spectra of deuterated proteins: Bovine Serum Albumin, Leptin, Insulin-like Growth Factor II, monoclonal antibody to ovarian cancer antigen CA125 and Osteopontin. The spectra exhibit changes in the relative amplitude and spectral width of certain peaks. New peaks not present in the non-deuterated sample are also observed. Ways for improving the deuteration of proteins by varying the temperature and dilution time are discussed. We propose the use of deuterated proteins to increase the sensitivity of immunoassays aimed for early diagnostic of diseases most notably cancer.
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A. Marcano O., A. Marcano O., Y. Markushin, Y. Markushin, N. Melikechi, N. Melikechi, D. Connolly, D. Connolly, } "Fourier transform infrared spectroscopy of deuterated proteins", Proc. SPIE 7049, Linear and Nonlinear Optics of Organic Materials VIII, 70490Z (2 September 2008); doi: 10.1117/12.794878; https://doi.org/10.1117/12.794878
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