28 August 2008 OLED-polypropylene bio-CD sensor
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Abstract
With the goal of developing microfluidic platforms for sensing applications, flash-free micro patterns were embossed in polypropylene surfaces with ultrasonic heating for a biosensing lab-on-CD application. The embossed features were designed to act as reservoirs, valves, and reaction chambers to allow, in combination with a compact sensing platform, the monitoring of analyte levels using a standard PC-CD player. To generate the compact sensor, as an example, we chose the photoluminescence (PL)-based detection of lactate and glucose using an OLED-based sensing platform. Once embossed, the surface energy of the plastic substrate was chemically modified to make it hydrophilic. Reagents, placed in separate reservoirs, were directed through burst valves towards a reaction chamber via CD rotation. Lactate or glucose were monitored by measuring the effect of the related dissolved oxygen level on the PL decay time of an oxygen-sensitive dye, following analyte oxidation catalyzed by a suitable specific oxidase enzyme. The results demonstrate the potential of integrating OLEDs as excitation sources in PL-based sensors with microfluidic CD-based platforms, including for simultaneous multiple analyses.
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Srikanth Vengasandra, Yuankun Cai, David Grewell, Joseph Shinar, Ruth Shinar, "OLED-polypropylene bio-CD sensor", Proc. SPIE 7054, Organic Field-Effect Transistors VII and Organic Semiconductors in Sensors and Bioelectronics, 70541H (28 August 2008); doi: 10.1117/12.794231; https://doi.org/10.1117/12.794231
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