The James Webb Space Telescope (JWST) is an infrared space telescope scheduled for launch in 2013. JWST has a 6.5 meter diameter deployable and segmented primary mirror, a deployable secondary mirror, and a deployable sun-shade. The optical train of JWST consists of the Optical Telescope Element (OTE), and the Integrated Science Instrument Module (ISIM), which contains four science instruments. When the four science instruments are integrated to ISIM at NASA Goddard Space Flight Center, the structure becomes the ISIM Element. The ISIM Element is assembled at ambient cleanroom conditions using theodolite, photogrammetry, and laser tracker metrology, but it operates at cryogenic temperature, and temperature-induced mechanical and alignment changes are measured using photogrammetry. The OTE simulator (OSIM) is a high-fidelity, cryogenic, telescope simulator that features a ~1.5 meter diameter powered mirror. OSIM is used to test the optical performance of the science instruments in the ISIM Element, including focus, pupil shear, and wavefront error. OSIM is aligned to the flight coordinate system in six degrees of freedom via OSIM-internal cryogenic mechanisms and feedback from alignment sensors. We highlight optical metrology methods, introduce the ISIM and the Science Instruments, describe the ambient alignment and test plan, the cryogenic test plan, and verification of optical performance of the ISIM Element in cryo-vacuum environment.