Large scale brain networks in epilepsy

Hitten P. Zaveri; Steven M. Pincus; Irina I. Goncharova; Robert B. Duckrow; Susan S. Spencer M.D.

doi:10.1117/12.801365

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3 September 2008 Large scale brain networks in epilepsy

Hitten P. Zaveri, Steven M. Pincus, Irina I. Goncharova, Robert B. Duckrow, Susan S. Spencer M.D.

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Proceedings Volume 7074, Advanced Signal Processing Algorithms, Architectures, and Implementations XVIII; 70740T (2008) https://doi.org/10.1117/12.801365
Event: Optical Engineering + Applications, 2008, San Diego, California, United States

Abstract

Two studies of brain networks, performed on interictal intracranial EEGs recorded during the presurgical evaluation of patients with epilepsy, are presented in this report. In the first we examine pairwise relationships between pre-defined brain regions in 12 patients, 6 with medial temporal onset of seizures and 6 with frontal and parietal onset of seizures. We demonstrate that differences, in pairwise relationships between brain regions, allow a distinction of these two groups of patients. In the second study we evaluate short, mid, and long-distance brain connectivity as a function of distance to the seizure onset area in another 2 patients. We demonstrate that the measures of brain connectivity distinguish between brain areas which are close to and far from the seizure onset area. The results of the two studies may help both define large scale brain networks involved in the generation of seizures, and localize the area of seizure onset.

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Hitten P. Zaveri, Steven M. Pincus, Irina I. Goncharova, Robert B. Duckrow, and Susan S. Spencer M.D. "Large scale brain networks in epilepsy", Proc. SPIE 7074, Advanced Signal Processing Algorithms, Architectures, and Implementations XVIII, 70740T (3 September 2008); https://doi.org/10.1117/12.801365

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