13 October 2008 The development of a real-time monitoring and auto-controlling PDT system
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Abstract
Measurement of concentration of photosensitizer, tissue oxygen can reveal information about tissue metabolism and effects of photodynamic therapy (PDT). The purpose of this study is to develop a monitoring and auto-controlling laser system for PDT instrument. The concentration of issue oxygen is detected by near-infrared spectroscopy (NIRS). The blood drug level of photosensitizer is monitored during PDT by fluorescence spectroscopy which was induced by 532 nm Laser. The Laser's output power and idle time can be determined by those monitored parameters. Thus, this system will provide insights into ways to enhance treatment's effectiveness and selectivity in clinical operation.
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Jiumin Yang, Jiumin Yang, Yingxin Li, Yingxin Li, Tiegen Liu, Tiegen Liu, Yu Zhao, Yu Zhao, "The development of a real-time monitoring and auto-controlling PDT system", Proc. SPIE 7129, Seventh International Symposium on Instrumentation and Control Technology: Optoelectronic Technology and Instruments, Control Theory and Automation, and Space Exploration, 71291S (13 October 2008); doi: 10.1117/12.807510; https://doi.org/10.1117/12.807510
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