In Situ Detection Of Tissular Respiration Arrest By NADH Laser Fluorimetry

Guy Renault; Martine Muffat-Joly; Juliette Polianski; Roger Ian Hardy; Remy Nottin; Michel Weiss; Jean-Louis Boutineau; Jean-Paul Binet; Jean-Jacques Pocidalo

doi:10.1117/12.937388

1 April 1987 In Situ Detection Of Tissular Respiration Arrest By NADH Laser Fluorimetry

Guy Renault, Martine Muffat-Joly, Juliette Polianski, Roger Ian Hardy, Remy Nottin, Michel Weiss, Jean-Louis Boutineau, Jean-Paul Binet, Jean-Jacques Pocidalo

Author Affiliations +

Proceedings Volume 0713, Optical Fibers in Medicine II; (1987) https://doi.org/10.1117/12.937388
Event: Cambridge Symposium-Fiber/LASE '86, 1986, Cambridge, MA, United States

Abstract

The continuous measurement of intratissular NADH concentration allows early detection of cellular respiration arrest during clinical situations, i.e. allows a non-destructive, in situ, continuous measurement of ATP formation. This detection enables the physician or surgeon to intervene during a phase of cellular respiration arrest, before structural cellular alterations occur, thereby preventing potential tissular necrosis. The method has now been validated in experimental cardiac surgery for the monitoring of myocardial preservation techniques in cardiopulmonary by-pass and in cardiac pharmacology. Its industrial development is currently under way. Preliminary investigation strongly suggest the vast potentials of this diagnostic method in both clinical and experimental fields.

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Guy Renault, Martine Muffat-Joly, Juliette Polianski, Roger Ian Hardy, Remy Nottin, Michel Weiss, Jean-Louis Boutineau, Jean-Paul Binet, and Jean-Jacques Pocidalo "In Situ Detection Of Tissular Respiration Arrest By NADH Laser Fluorimetry", Proc. SPIE 0713, Optical Fibers in Medicine II, (1 April 1987); https://doi.org/10.1117/12.937388

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