18 November 2008 Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions: two clinical cases
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Proceedings Volume 7138, Photonics, Devices, and Systems IV; 71380K (2008) https://doi.org/10.1117/12.817984
Event: Photonics, Devices, and Systems IV, 2008, Prague, Czech Republic
Abstract
Photodynamic diagnosis (PDD) is promising method of visualisation of premalignant and malignant lesions. PDD is consisted of two main agents: special chemical compound which is called photosensitizer and light. Photosensitizer has affinity to fast proliferating cells such as pre- or malignant. During light irradiation (with proper wavelength - corresponding to absorption peak of photosensitizer) photosensitizer gains energy and passes into excited singlet state S1. Returning to basic singlet state Sn, leads to fluorescence. Due to difference between concentration of photosensitizer in lesion and normal tissue it is possible to obtain high contrast image of lesion. Case #1: 53 years old woman with basal cell carcinoma (BCC) in nasal region; 20% delta-aminolevulinic acid as a precursor of photosensitizer on eucerin base was used. Case #2: 57 years old woman with multifocal oral leukoplakia on cheek mucosa and tongue; 2% chlorophyll gel as photosesitizer was used. All photographs were taken in white light without any filter and in blue and UV light with orange filter: in both cases the total area of the lesions appeared to be larger than it has been clinically observed. Thus, the PDD might be helpful in evaluation of margins of surgical excision of such lesions.
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Kamil Jurczyszyn, Piotr Ziólkowski, Beata Osiecka, Hanna Gerber, Magdalena Dziedzic, "Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions: two clinical cases", Proc. SPIE 7138, Photonics, Devices, and Systems IV, 71380K (18 November 2008); doi: 10.1117/12.817984; https://doi.org/10.1117/12.817984
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