CONFERENCE PROCEEDINGS
Advanced Search >
Home > Proceedings > Volume 7139 > Article
Translator Disclaimer
30 December 2008 Retinal intrinsic optical signal and optical coherence tomography
Alexandre R. Tumlinson; Boris Hermann; Tom H. Margrain; Bernd Hofer; Boris Považay; Wolfgang Drexler
Author Affiliations +
Proceedings Volume 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics; 71390S (2008) https://doi.org/10.1117/12.819401
Event: 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics, 2008, Canterbury, United Kingdom
Abstract
The amount of light backscattered from neural tissues changes as a function of activation and is the basis of intrinsic optical signal (IOS). Typically IOS is observed by looking at darkfield scatter with a CCD camera. The retina is a calculating portion of the central nervous grey matter with an optical quality window, and is likewise easily stimulated optically. Therefore the retina makes a natural model for observing neural interactions with optical tools. Optical coherence tomography (OCT) is an imaging modality that provides depth resolved maps of the amount of light backscattered from tissue that has wide clinical use for observing structural defects associated with ophthalmic disease. It is therefore also natural to use OCT as means to observe intrinsic optical signal in the retina. Indeed, OCT has recently been used to observe an increase in backscatter at the level of the outer photoreceptor segment after bleaching light stimulation in an excised rabbit retina. We are currently attempting to translate this result towards a diagnostic technique for photoreceptor dysfunction in human patients. Currently patient motion and physiological noise present barriers that must be overcome with increases in technological and experimental sophistication. This proceeding reviews current understanding of retinal intrinsic optical signal and discusses its measurement challenge.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Alexandre R. Tumlinson, Boris Hermann, Tom H. Margrain, Bernd Hofer, Boris Považay, and Wolfgang Drexler "Retinal intrinsic optical signal and optical coherence tomography", Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390S (30 December 2008); doi: 10.1117/12.819401; https://doi.org/10.1117/12.819401
ACCESS THE FULL ARTICLE
PERSONAL SIGN IN
Full access may be available with your subscription
 
Forgot your username?
Forgot your password?
No SPIE account? Create an account
or Institutional Sign In via Shibboleth
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $14.40
Non-members: $18.00 ADD TO CART
PROCEEDINGS
 11 PAGES
DOWNLOAD PDF SAVE TO MY LIBRARY
SHARE
GET CITATION
< Previous Article
|
Next Article >
Advertisement
Advertisement
KEYWORDS
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top