A novel biosensor based on up-converting phosphor technology (UPT) was developed several years ago. It is a kind
of optical biosensor using up-converting phosphor (UCP) particles as the biological marker. From then on, some
improvements have been made for this UPT-based biosensor.
The primary aspects of the improvement lie in the control system. On one hand, the hardware of the control system
has been optimized, including replacing two single chip microcomputers (SCM) with only one, the optimal design of the
keyboard interface circuit and the liquid crystal module (LCM) control circuit et al.. These result in lower power
consumption and higher reliability. On the other hand, a novel signal processing algorithm is proposed in this paper,
which can improve the automation and operating simplicity of the UPT-based biosensor.
It has proved to have high sensitivity (~ng/ml), high stability and good repeatability (CV<5%), which is better than
the former system. It can meet the need of some various applications such as rapid immunoassay, chemical and
biological detection and so on.