2 February 2009 Design and realization of label-free optical immunosensor based on porous silicon microcavities
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Abstract
We report the experimental demonstration of a novel label-free optical immunosensor based on porous silicon microcavity for the detection of Hydroxysafflor yellow A (HYSA). HYSA antibodies were immobilized into the porous silicon using standard amino-silane and glutaraldehyde chemistry. We monitor the shift of the resonance dip in the reflectance spectrum when HYSA-BSA is attached to the porous silicon microcavity. The label-free immunosensor is simple and exhibit excellent sensitivity for HYSA antibodies with a sensitivity of 0.91nm/ng.
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Xiao-yi Lü, Xiao-yi Lü, Tao Xue, Tao Xue, Zhen-hong Jia, Zhen-hong Jia, Hua-wei Shao, Hua-wei Shao, Shi-bin Hou, Shi-bin Hou, Fu-chun Zhang, Fu-chun Zhang, } "Design and realization of label-free optical immunosensor based on porous silicon microcavities", Proc. SPIE 7157, 2008 International Conference on Optical Instruments and Technology: Advanced Sensor Technologies and Applications, 71571E (2 February 2009); doi: 10.1117/12.811386; https://doi.org/10.1117/12.811386
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