19 February 2009 In vivo multiphoton tomography in skin aging studies
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Abstract
High-resolution clinical multiphoton tomography based on the femtosecond laser system DermaInspect™ has been performed on hundreds of patients and volunteers in Australia, Asia, and Europe. The system enables the in vivo detection of the elastin and the collagen network as well as the imaging of melanin clusters in aging spots. The epidermis-dermis junction can be detected with submicron resolution. One major applications of this novel HighTech imaging tool is the determination of the skin aging index SAAID as well as the study of the effects of anti-aging products. In particular, the stimulated biosynthesis of collagen can be investigated over long periods of time. The system with its sub-500 nm lateral resolution is able to image age-related modifications of the extracellular matrix on the level of a single elastin fiber.
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Karsten König, Rainer Bückle, Martin Weinigel, Johannes Köhler, Peter Elsner, Martin Kaatz, "In vivo multiphoton tomography in skin aging studies", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71610H (19 February 2009); doi: 10.1117/12.813398; https://doi.org/10.1117/12.813398
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