23 February 2009 Monitoring tissue response during non-ablative irradiation of photorejuvenation with optical coherence tomography
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Abstract
With low risk of complications and no down-time, the non-ablative photorejuvenation is playing an increasing role in the therapy of the photodamaged skin. The light dose is one of the key factors that affect the performance of the photorejuvenation. Monitoring the tissue response during the procedure of laser irradiation would help to determine whether the light dose is appropriate. In this study, we developed a new approach to monitor the instant response of tissue irradiated by laser device by measuring the change of the total attenuation coefficient of the tissue with optical coherence tomography. The total attenuation coefficient was deduced from the raw data obtained by OCT with single scattering mode. Spatial and temporal equalizations were employed to improve the signal-to-noise ratio. We measured in vivo the total attenuation coefficients of the mouse back skin before and after laser irradiation. The total attenuation coefficients of the tissue reduced approximately 60% immediately after laser irradiation and then kept constant in a short time. The reduction of the attenuation coefficient depended on the light dose. These results demonstrated that the new approach could be a potential tool for monitoring in clinic in the future.
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Yimei Huang, Yimei Huang, Wei Gong, Wei Gong, Shusen Xie, Shusen Xie, } "Monitoring tissue response during non-ablative irradiation of photorejuvenation with optical coherence tomography", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 716110 (23 February 2009); doi: 10.1117/12.808587; https://doi.org/10.1117/12.808587
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