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23 February 2009 Design of a compact laparoscopic probe for optical stimulation of the cavernous nerves
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Abstract
The cavernous nerves are responsible for erectile function and course along the prostate surface, varying in size and location among patients, making preservation of sexual function challenging after prostate cancer surgery. Electrical stimulation has proven inconsistent and unreliable in identifying these nerves and evaluating nerve function. Optical stimulation of the rat cavernous nerves has recently been reported as a alternative to electrical stimulation, with potential advantages including noncontact stimulation and improved spatial selectivity. This study describes the design of a compact laparoscopic probe for future clinical use in optical nerve stimulation. The 10-Fr (3.4-mm-OD) prototype laparoscopic probe includes an aspheric lens for collimation of the laser beam with a 0.8- mm-diameter spot, coupled with a 200-μm-core optical fiber. A 45° gold-coated rod mirror in the probe tip provides side-firing delivery of the laser radiation. The probe handle houses a miniature linear motorized stage for lateral scanning of the probe tip over a 25-mm line along the prostate surface. A 5.5-W Thulium fiber laser with tunable wavelength range of 1850-1880 nm was tested with the probe. The probe fits through a standard 5-mm-ID laparoscopic port and is capable of delivering pulse energies up to 8 mJ (1.6 J/cm2) at a 2.5-ms pulse duration, well above the threshold (~ 0.35 J/cm2) for optical stimulation of the cavernous nerves.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Serhat Tozburun and Nathaniel M. Fried "Design of a compact laparoscopic probe for optical stimulation of the cavernous nerves", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 716113 (23 February 2009); https://doi.org/10.1117/12.807484
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