23 February 2009 Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis
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Abstract
Introduction: While a variety of materials has been evaluated for replacement of human middle ear ossicles following inflammation, titanium and its alloys have shown excellent sound transmission properties and biocompatibility. However, cartilage thickness at the tympanic membrane interface deteriorates over time, while fibrous tissue formation may dislodge the titanium prosthesis. This study was performed to evaluate the effect of microstructures on titanium surfaces in contact with adjacent biological tissue. Materials and Methods: Titanium samples of 5mm diameter and 0,25mm thickness were structured by means of a Ti:Sapphire femtosecond laser operating at 970nm. The structures applied were lines of parabolic shape (cross-sectional) of 5µm (parallel), 5µm (cross-hatch) and 10µm width (parallel). The inter-groove distance between two maxima was exactly twice the line width. Results: Lines smaller than 5µm were not feasible due to the natural irregularity of the basic material with pits and level changes of up to 2µm. The process showed little debris and constant microstructure shape over the whole structured area (2x2mm). The resulting debris was examined for toxic by-products on human fibrobcytes and chondrocytes. Discussion: The results show that microstructures can be applied on titanium surfaces for human implantation with reproducible and constant shapes. Further studies will focus on cell culture which has suggested a relative selectivity for chondrocyte compared to fibrocyte growth in earlier studies with selected microstructures.
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Justus Ilgner, Slavomir Biedron, Elena Fadeeva, Boris Chichkov, Martin Westhofen, "Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71611X (23 February 2009); doi: 10.1117/12.806691; https://doi.org/10.1117/12.806691
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