High speed high resolution in vivo imaging of healthy rat retinas with FD-OCT operating at 1060nm

Sepideh Hariri; Aphrodite Dracopoulos; Alireza Akhlagh Moayed; Chulho Hyun; Zhao Ren; Prabakar Puvanathasan; Shelley Boyd; Kostadinka Bizheva

doi:10.1117/12.809768

23 February 2009 High speed high resolution in-vivo imaging of healthy rat retinas with FD-OCT operating at 1060nm

Sepideh Hariri, Aphrodite Dracopoulos, Alireza Akhlagh Moayed, Chulho Hyun, Zhao Ren, Prabakar Puvanathasan, Shelley Boyd, Kostadinka Bizheva

Author Affiliations +

Proceedings Volume 7163, Ophthalmic Technologies XIX; 716305 (2009) https://doi.org/10.1117/12.809768
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

A high speed (47,000 A-scan/s), high resoluiton FD-OCT system, operating in the 1060nm wavelength range was used to acquire in-vivo 3D image of healthy and pathological rat retinas. The images were acquired with ~4.3µm axial and ~5µm lateral resolution in the rat eye and 102dB sensitivity at 1.3mW optical power of the imaging beam. The images of the healthy rat retinas show increased penetration into the choroid, clear visualization of all intra-retinal layers and the choroidal blood network, as well as part of the underlying sclera. The high imaging resolution of the OCT system is also sufficient for resolving tiny capillaries imbedded in the inner - and outer plexiform layers of the retina. The high data acquisition rate of the FD-OCT system combined with the high axial resolution is also suitable for probing light induced physiological processes in the retina simultaneously with the morphological imaging.

Citation Download Citation

Sepideh Hariri, Aphrodite Dracopoulos, Alireza Akhlagh Moayed, Chulho Hyun, Zhao Ren, Prabakar Puvanathasan, Shelley Boyd, and Kostadinka Bizheva "High speed high resolution in-vivo imaging of healthy rat retinas with FD-OCT operating at 1060nm", Proc. SPIE 7163, Ophthalmic Technologies XIX, 716305 (23 February 2009); https://doi.org/10.1117/12.809768

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