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18 February 2009 Intraocular tissue ablation using an optical fibre to deliver the 5th harmonic of a Nd:YAG
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Proceedings Volume 7163, Ophthalmic Technologies XIX; 71630X (2009) https://doi.org/10.1117/12.808138
Event: SPIE BiOS, 2009, San Jose, California, United States
Abstract
We report the evaluation of a system which delivers the 5th harmonic of an Nd:YAG (213nm) via optical fibre to ocular tissue sites. The 213nm beam is concentrated, using a hollow glass taper, prior to launch into 200 μm or 600 μm core diameter silica/silica optical fibre. The fibre tip was tapered to enhance the fluence delivered. An operating window of fluence values that could be delivered via 330 - 1100mm lengths of optical fibre was determined. The lower value of 0.2J/cm2 determined by the ablation threshold of the tissue and the upper value of 1.3J/cm2 by the launch, transmission and tip characteristics of the optical fibre. The fluence output decreased as a function of both transmitted pulse energy and number of pulses transmitted. Fresh retinal tissue was cleanly ablated with minimal damage to the surrounding tissue. Lesions were generated using 1, 3 and 10 pulses with fluences from 0.2 to 1.0J/cm2. The lesion depth demonstrated clear dose dependence. Lesions generated in ex vivo preparations of human trabecular meshwork in a fluid environment also demonstrated dose dependence, 50 pulses being sufficient to create a hole within the trabecular meshwork extending to Schlemm's canal. The dose dependence of the ablation depth combined with the ability of this technique to create a conduit through to Schlemm's canal demonstrates the potential of this technique for ophthalmological applications requiring precise and controlled intraocular tissue removal and has potential applications in the treatment and management of glaucoma.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Joseph Miller, Xiaobo Yu, Paula K. Yu, Stephen J. Cringle, and Dao-Yi Yu "Intraocular tissue ablation using an optical fibre to deliver the 5th harmonic of a Nd:YAG", Proc. SPIE 7163, Ophthalmic Technologies XIX, 71630X (18 February 2009); https://doi.org/10.1117/12.808138
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