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23 February 2009 In vivo functional retinal optical coherence tomography fOCT
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Proceedings Volume 7163, Ophthalmic Technologies XIX; 71631J (2009)
Event: SPIE BiOS, 2009, San Jose, California, United States
Probing the retina with flicker light of defined frequencies allowed to offset the detection for intrinsic signals from proband motion artifacts as well as blood flow. In addition the fast imaging sequence capability of FDOCT is promising for the assessment of fast physiologic changes within retinal structures. For the present study two measurement protocols are evaluated: first, taking fast tomogram series across a flickered region, and then constructing via frequency analysis and bandpass filtering a functional OCT tomogram similar to fMRI. The second protocol consists of a fast local A-scan series at 17kHz rate with 1Hz flicker. 'Light-on' time is 250ms. 'Lights off' time is 750ms. 500ms before 'light-on' is used for calculating the baseline. Finally the average over 5 cycles is taken. A clear negative response is found at the outer photoreceptor segment for both 'light-on' and 'light-off' edge. The response appears to be stronger for the 'light off' edge. The shape of the responses is analysed and might eventually be used in linear regression models to enhance the sensitivity of our fOCT approach.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Rainer A. Leitgeb and Tilman Schmoll "In vivo functional retinal optical coherence tomography fOCT", Proc. SPIE 7163, Ophthalmic Technologies XIX, 71631J (23 February 2009);

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