19 February 2009 Design of a hybrid amine functionalized polyacrylamide hydrogel-porous silicon optical sensor
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This work focuses on the development of a proof-of-concept optical sensor design that incorporates an amine-functionalized polyacrylamide hydrogel into a 1D porous silicon (PSi) photonic crystal. The PSi acts as both a template and a transducer capable of detecting morphological and dielectric changes in the incorporated hydrogel structure. Free radical copolymerization of acrylamide (AAm) and N-(3- aminopropyl)-methacrylamide (NA) monomers was utilized to form copolymer chains with a controlled concentration of nucleophilic amine moieties. These amine groups facilitated chemical cross-linking of the copolymer chain to generate hydrogel networks. A molar fraction of >2 mol% of NA monomer was needed to facilitate a visibly gelatinous hydrogel in a 5 wt% polymer solution. Addition of sodium formate (chain transfer agent) during copolymer synthesis facilitated decreased copolymer chain length and improved infiltration of the copolymer into the p-type PSi mesoporous sensor (pore diameters ~20-30 nm). Controlled cross-linking of the copolymer chains was completed with using glutaraldehyde, as a model system, to form a hydrogel network that could be optically monitored by the incorporated PSi sensor. These results lay foundation for extending this versatile methodology towards the design of an affinity based complimentary target-probe system to create a hybrid target-responsive hydrogel-PSi chemical sensor.
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Lisa M. Bonanno, Lisa A. DeLouise, "Design of a hybrid amine functionalized polyacrylamide hydrogel-porous silicon optical sensor", Proc. SPIE 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems, 71670F (19 February 2009); doi: 10.1117/12.809201; https://doi.org/10.1117/12.809201

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