Robust sensing films for pathogen detection and medical diagnostics

Aaron S. Anderson; Andrew M. Dattelbaum; Harshini Mukundan; Dominique N. Price; W. Kevin Grace; Basil I. Swanson

doi:10.1117/12.809383

19 February 2009 Robust sensing films for pathogen detection and medical diagnostics

Aaron S. Anderson, Andrew M. Dattelbaum, Harshini Mukundan, Dominique N. Price, W. Kevin Grace, Basil I. Swanson

Proceedings Volume 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems; 71670Q (2009) https://doi.org/10.1117/12.809383
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Our team has developed polyethylene glycol (PEG)-modified, self-assembled monolayers (SAMs) for biological detection on either planar or spherical substrates, which resist non-specific binding while facilitating specific ligand attachment. The preparation and characterization of these thin films, their validation against B. anthracis protective antigen (PA) in a sandwich assay format, and the application of these thin films for quantitative analysis of several medically interesting targets (breast cancer, tuberculosis, and influenza) will be shown.

Citation Download Citation

Aaron S. Anderson, Andrew M. Dattelbaum, Harshini Mukundan, Dominique N. Price, W. Kevin Grace, and Basil I. Swanson "Robust sensing films for pathogen detection and medical diagnostics", Proc. SPIE 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems, 71670Q (19 February 2009); https://doi.org/10.1117/12.809383

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