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24 February 2009 The broadest spectral bandwidth suitable for in-vivo UHROCT imaging of human and animal retina at 1060nm
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Abstract
A computational model for an "ideal" light source for in-vivo UHROCT imaging of human and animal retina is presented. The model considers parameters such as the wavelength dependent absorption of water, the length of the human or animal eye, the power limitations for the imaging beam as defined in the ANSI standard, etc., to determinethe broadest possible spectral bandwidth that can result in the best axial OCT resolution in the 1060nm wavelength region. A custom light source with a re-shaped spectrum was used to verify experimentally the results from the computational model. 4.3µm axial OCT resolution was achieved experimentally in free space, corresponding to 3µm resolution in retinal tissue. A custom imaging probe was developed and optimized with ZEMAX to result in 5 µm transverse resolution in the rat retina. 2D and 3D OCT tomograms acquired in-vivo from rat retinas show visualization of tiny capillaries imbedded in the inner and outer plexiform layers of the rat retinas.
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Sepideh Hariri, Alireza A. Moayed, Chulho Hyun, Vladimir R. Shidlovski, Aphrodite Dracopoulos, Shelley Boyd, and Kostadinka Bizheva "The broadest spectral bandwidth suitable for in-vivo UHROCT imaging of human and animal retina at 1060nm", Proc. SPIE 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII, 716807 (24 February 2009); doi: 10.1117/12.809716; https://doi.org/10.1117/12.809716
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