20 February 2009 Spectral Doppler imaging of micro-vasculature response to laser irradiation
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Doppler Optical Coherence Tomography (DOCT) imaging of in-vivo retinal blood flow was widely studied as efforts of research community to push this technology into clinic. Spectral Doppler imaging of DOCT has been demonstrated as a quantification method of in-vivo pulsatile retinal blood flow in human eye. This technology has the all the advantages inherited from OCT comparing to Doppler ultrasound. Comparing to normal spatial-distributed color Doppler imaging of DOCT, spectral Doppler imaging can reveal more haemodynamics details on the time dimension. Although resistance index (RI) of a micro-vascular can be measured in vivo from human retina, the clinical significance of RI measurements still needs to be investigated. In vitro experiment conduced with ultrasound has demonstrated the higher vascular resistance value is associated with the higher RI measured assuming the constant compliance of vascular tube. In this study, the rodent window-chamber model (RWCM) was used as a platform to investigate the RI change as the micro-vasculature response to laser irradiation. The higher RI was measured after the occlusion of two veins (should it be arterials) that was verified with laser speckle imaging in our preliminary experiment results.
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Bin Rao, Bin Rao, Wangcun Jia, Wangcun Jia, Lingfeng Yu, Lingfeng Yu, Bernard Choi, Bernard Choi, Ronald M. Kurtz, Ronald M. Kurtz, J. Stuart Nelson, J. Stuart Nelson, Zhongping Chen, Zhongping Chen, "Spectral Doppler imaging of micro-vasculature response to laser irradiation", Proc. SPIE 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII, 71681T (20 February 2009); doi: 10.1117/12.809692; https://doi.org/10.1117/12.809692

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