24 February 2009 Spinning wave plate design for retinal birefringence scanning
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To enhance foveal fixation detection while bypassing the deleterious effects of corneal birefringence in retinal birefringence scanning (RBS), we developed a new RBS design introducing a double-pass spinning half wave plate (HWP) and a fixed double-pass retarder into the optical system. Utilizing the measured corneal birefringence from a data set of 300 human eyes, an algorithm and a related computer program, based on Mueller-Stokes matrix calculus, were developed in MATLAB for optimizing the properties of both wave plates. Foveal fixation detection was optimized with the HWP spun 9/16 as fast as the circular scan, with the fixed retarder having a retardance of 45° and fast axis at 90°. With this new RBS design, a significant statistical improvement of 7.3 times in signal strength, i.e. FFT power, was achieved for the available data set compared with the previous RBS design. The computer-model-optimized RBS design has the potential not only for eye alignment screening, but also for remote fixation sensing and eye tracking applications.
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K. Irsch, K. Irsch, B. I. Gramatikov, B. I. Gramatikov, Y.-K. Wu, Y.-K. Wu, D. L. Guyton, D. L. Guyton, } "Spinning wave plate design for retinal birefringence scanning", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691F (24 February 2009); doi: 10.1117/12.803344; https://doi.org/10.1117/12.803344

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