A coupled radiative transfer and diffusion approximation model for the solution of the forward problem and the a-priori fluorophore distribution estimation in fluorescence imaging

D. Gorpas; D. Yova; K. Politopoulos

doi:10.1117/12.808116

20 February 2009 A coupled radiative transfer and diffusion approximation model for the solution of the forward problem and the a-priori fluorophore distribution estimation in fluorescence imaging

D. Gorpas, D. Yova, K. Politopoulos

Author Affiliations +

Proceedings Volume 7171, Multimodal Biomedical Imaging IV; 71710A (2009) https://doi.org/10.1117/12.808116
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Although fluorescence imaging has been applied in tumour diagnosis from the early 90s, just the last few years it has met an increasing scientific interest due to the advances in the biophotonics field and the combined technological progress of the acquisition and computational systems. In addition there are expectations that fluorescence imaging will be further developed and applied in deep tumour diagnosis in the years to come. However, this evolving field of imaging sciences has still to encounter important challenges. Among them is the expression of an accurate forward model for the solution of the reconstruction problem. The scope of this work is to introduce a three dimensional coupled radiative transfer and diffusion approximation model, applicable on the fluorescence imaging. Furthermore, the solver incorporates the super-ellipsoid models and sophisticated image processing algorithms to additionally provide a-priori estimation about the fluorophores distribution, information that is very important for the solution of the inverse problem. Simulation experiments have proven that the proposed methodology preserves the accuracy levels of the radiative transfer equation and the time efficacy of the diffusion approximation, while in the same time shows extended success on the registration between acquired and simulated images.

Citation Download Citation

D. Gorpas, D. Yova, and K. Politopoulos "A coupled radiative transfer and diffusion approximation model for the solution of the forward problem and the a-priori fluorophore distribution estimation in fluorescence imaging", Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710A (20 February 2009); https://doi.org/10.1117/12.808116

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

3D modeling

Image segmentation

Chemical elements

Diffusion

Imaging systems

Molecular imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years