We hypothesize that in the presence of reduced oxygen delivery and extraction, blood flow will be redistributed in order
to protect the most vital organs (e.g., brain and heart) by increasing their regional blood flow, while O2 delivery to the
less vital organs (e.g., GI tract or urethral wall) will diminish. Evaluation of mitochondrial function in vivo could be
done by monitoring the oxidation reduction state of the respiratory chain. Thus, the NADH redox state of less vital
organs could serve as an indicator of overall O2 imbalance as well as an endpoint of resuscitation. We have therefore
tested, in a pig model, a new medical device providing real time data on NADH redox state and tissue blood flow- TBF
This device contains a modified three way Foley catheter with a fiber optic probe which connects the measurement unit
to the tested tissue. Female pigs underwent graded hemorrhage (GH) or Aortic clamping (AC). The main effects of GH
started when blood volume decreased by 30%. At 40% blood loss, minimal levels of TBF were correlated to the maximal
NADH levels. The values of the 2 parameters returned to baseline after retransfusion of the shed blood. Aortic clamping
led to significant decrease in TBF while NADH levels increased. After aortic declamping the parameters recovered to
normal values. Due to the short length of the urethra in female pigs and the instable contact between the probe and the
tissue, inconsistency of the responses was observed.
Our preliminary results show that the CritiView may be a useful tool for the detection of body O2 imbalance.