Angular domain optical projection tomography in turbid media

Fartash Vasefi; Bozena Kaminska; Kevin Jordan; Glenn H. Chapman; Jeffrey J. L. Carson

doi:10.1117/12.809394

23 February 2009 Angular domain optical projection tomography in turbid media

Fartash Vasefi; Bozena Kaminska; Kevin Jordan; Glenn H. Chapman; Jeffrey J. L. Carson

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71740D (2009) https://doi.org/10.1117/12.809394
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Most high-resolution optical tomography techniques employ coherence domain or time domain methodologies to capture non-scattered photons in turbid media. Angular Domain Optical Projection Tomography (ADOPT) uses an angular filter array (AFA) to observe photons that propagate through a specimen with small angular deviation. We constructed an ADOPT system consisting of an AFA micro-machined silicon micro-tunnel array with each micro-tunnel 60 μm wide, 60 μm high, 10 mm long, and separated by 5 μm thick walls. The range of acceptance angles was 0° to 0.5°. The system also included an 808 nm CW diode laser, beam shaping optics, a sample cuvette, a Keplerian lens system, and a CMOS camera. Testing was performed with a target consisting of two graphite rods (0.9 mm diameter) suspended in the cuvette by a rotation stage. The target was placed in a manner that the line of laser light was perpendicular to the long axis of the rods. A multitude of projections were collected at increments of 1.8° and compiled into a sinogram. A transverse image was reconstructed from the sinogram using filtered backprojection. The submillimeter targets embedded in the 2 cm thick scattering medium (reduced scattering coefficient ≤ 2.4 cm^-1) were discernable in both the sinograms and the reconstructed images. The results suggest that ADOPT may be a useful technique for tomographic imaging of thick biological specimens (i.e. up to 8 mm across).

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Fartash Vasefi, Fartash Vasefi, Bozena Kaminska, Bozena Kaminska, Kevin Jordan, Kevin Jordan, Glenn H. Chapman, Glenn H. Chapman, Jeffrey J. L. Carson, Jeffrey J. L. Carson, } "Angular domain optical projection tomography in turbid media", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740D (23 February 2009); doi: 10.1117/12.809394; https://doi.org/10.1117/12.809394

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