23 February 2009 3D optical contrast-recovery in MR guided diffuse optical spectroscopy
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It is well known that diffuse optical tomography (DOT) has limited spatial resolution, and sufficient contrast recovery is limited to lesions greater than ~6 mm[1]. However, with the addition of multimodality methods that combine high spatial resolution imaging, such as MRI, it has been shown that quantification and feature recovery improves[2]. However, it is not known how well MRg-DOS will perform with characterizing small lesions in 3D. These limits need to be established in order to determine the practical limitations of optical imaging. This paper investigates the contrast resolution limits of 3 dimensional MRg-DOS. Short irregular inclusions of various diameters are added to a homogeneous background. Two case studies are presented which represent these limiting situations.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Colin Carpenter, Colin Carpenter, Subhadra Srinivasan, Subhadra Srinivasan, Brian Pogue, Brian Pogue, Keith D. Paulsen, Keith D. Paulsen, } "3D optical contrast-recovery in MR guided diffuse optical spectroscopy", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740G (23 February 2009); doi: 10.1117/12.808943; https://doi.org/10.1117/12.808943

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