Image-guided optical spectroscopy in diagnosis of osteoarthritis by combining spectral and spatial a priori information

Zhen Yuan; Qizhi Zhang; Huizhu Jiang; Eric S. Sobel; Huabei Jiang

doi:10.1117/12.809556

12 February 2009 Image-guided optical spectroscopy in diagnosis of osteoarthritis by combining spectral and spatial a priori information

Zhen Yuan, Qizhi Zhang, Huizhu Jiang, Eric S. Sobel, Huabei Jiang

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71740K (2009) https://doi.org/10.1117/12.809556
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

A multi-modality imaging approach and instrument that integrate optical imaging system and near-infrared spectroscopy into an x-ray tomosynthesis setup have been employed to perform a clinical study of image-guided spectroscopy on osteoarthritis (OA) in the finger joints. The multiwavelength spectroscopy of the joints using x-ray-guided spatial constraints provides 3D images of oxygen saturation and water content with high resolution and improved quantitative capability. Based on the recovered quantitative results from 18 healthy volunteers and 22 patients, we observed that oxygen saturation and water content were significant discriminators for differentiation of healthy joints from diseased ones. The recovered images appear to show that the OA joints have high water values and decreased oxygen saturation.

Citation Download Citation

Zhen Yuan, Qizhi Zhang, Huizhu Jiang, Eric S. Sobel, and Huabei Jiang "Image-guided optical spectroscopy in diagnosis of osteoarthritis by combining spectral and spatial a priori information", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740K (12 February 2009); https://doi.org/10.1117/12.809556

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