12 February 2009 Pressure-enhanced near-infrared breast imaging: toward cancer patient imaging
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An NIRS tomography system that can simultaneously acquire data at three wavelengths has been developed to measure changes in physiological properties with 15 second time resolution. The results of homogenous and heterogeneous blood phantom studies indicated that the R2 values between average estimated total hemoglobin (HbT) values and blood concentrations are 0.99 and 0.9, respectively. In preliminary normal subject clinical trials, a cohort of normal subjects were tested by acquiring the series images as well as the pressure is adding to and releasing from the breast. The recovered data shown that by adding measurable pressure, HbT is reduced and the maximum HbT reduction is correlated to the Body Mass Index.
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Shudong Jiang, Shudong Jiang, Brian W. Pogue, Brian W. Pogue, Ashley M. Laughney, Ashley M. Laughney, Keith D. Paulsen, Keith D. Paulsen, } "Pressure-enhanced near-infrared breast imaging: toward cancer patient imaging", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740S (12 February 2009); doi: 10.1117/12.808071; https://doi.org/10.1117/12.808071

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