12 February 2009 In vivo studies of 144 breast masses by phase contrast diffuse optical tomography
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Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71740X (2009); doi: 10.1117/12.809478
Event: SPIE BiOS, 2009, San Jose, California, United States
We report our continued study of phase-contrast diffuse optical tomography (PCCDOT) for evaluating its fidelity in distinguishing malignant breast lesions form benign ones. 144 breast masses were examined from 134 patients, aging from 22~82 with the mean age of 56. Tissue optical parameters including refractive index, and absorption and scattering coefficients, were obtained and compared with their corresponding biopsy/pathology reports. In consistent with our previous study, malignant masses tended to have a decreased refractive index relative to their surrounding normal tissue, which acts as the key character to differentiate them from benign masses. The results show that the specificity is improved significantly over the previous smaller scale study (85% vs. 70%) due to the addition of significantly more benign cases, while the sensitivity stays about the same (81% vs. 82%) due to the similar number of malignant cases used compared to the smaller scale study.
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Ruixin Jiang, Xiaoping Liang, Qizhi Zhang, Stephen R. Grobmyer, Laurie L. Fajardo, Huabei Jiang, "In vivo studies of 144 breast masses by phase contrast diffuse optical tomography", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740X (12 February 2009); doi: 10.1117/12.809478; https://doi.org/10.1117/12.809478

Refractive index



Diffuse optical tomography

Tissue optics



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