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12 February 2009 A continuous-wave mode elliptic-region-based DOT methodology based on BEM-diffusion modeling
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Acquisition of the optical structures within a biological body is critical to all the diffuse light imaging modalities, such as diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT). On an assumption of the optical homogeneity within the organs, it can be cast as a shape-based DOT issue, which aims at simultaneously reconstructing the boundary-describing parameters and optical properties of the disjoint domains of distinct tissue types. As the first step to the solution of this issue, we propose here a continuous-wave mode, elliptic-region-based DOT scheme. The methodology employs the boundary-element-method (BEM) solution to the diffusion equation as the forward model, and solves a nonlinear inverse issue that seeks an optimal boundary configuration as well as the optical properties to minimize the residual norm between measured and predicted data. The proposed scheme is validated using simulated data for a cylindrical geometry embedding two absorption- and scattering-contrasting ellipses at different noise levels.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Pingqiao Ruan, Yanfang Liu, Feng Gao, Huijuan Zhao, and Meng Jin "A continuous-wave mode elliptic-region-based DOT methodology based on BEM-diffusion modeling", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741S (12 February 2009);

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