12 February 2009 In vivo trans-rectal ultrasound coupled trans-rectal near-infrared optical tomography of canine prostate bearing transmissible venereal tumor
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Abstract
In vivo trans-rectal near-infrared (NIR) optical tomography is conducted on a tumor-bearing canine prostate with the assistance of trans-rectal ultrasound (TRUS). The canine prostate tumor model is made possible by a unique round cell neoplasm of dogs, transmissible venereal tumor (TVT) that can be transferred from dog to dog regardless of histocompatibility. A characterized TVT cell line was homogenized and passed twice in subcutaneous tissue of NOD/SCID mice. Following the second passage, the tumor was recovered, homogenized and then inoculated by ultrasound guidance into the prostate gland of a healthy dog. The dog was then imaged with a combined trans-rectal NIR and TRUS imager using an integrated trans-rectal NIR/US applicator. The image was taken by NIR and US modalities concurrently, both in sagittal view. The trans-rectal NIR imager is a continuous-wave system that illuminates 7 source channels sequentially by a fiber switch to deliver sufficient light power to the relatively more absorbing prostate tissue and samples 7 detection channels simultaneously by a gated intensified high-resolution CCD camera. This work tests the feasibility of detecting prostate tumor by trans-rectal NIR optical tomography and the benefit of augmenting TRUS with trans-rectal NIR imaging.
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Zhen Jiang, Zhen Jiang, G. Reed Holyoak, G. Reed Holyoak, Kenneth E. Bartels, Kenneth E. Bartels, Jerry W. Ritchey, Jerry W. Ritchey, Guan Xu, Guan Xu, Charles F. Bunting, Charles F. Bunting, Gennady Slobodov, Gennady Slobodov, Jerzy S. Krasinski, Jerzy S. Krasinski, Daqing Piao, Daqing Piao, } "In vivo trans-rectal ultrasound coupled trans-rectal near-infrared optical tomography of canine prostate bearing transmissible venereal tumor", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741U (12 February 2009); doi: 10.1117/12.807990; https://doi.org/10.1117/12.807990
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