23 February 2009 Frequency domain 3D simplified spherical harmonics approximation: development, validation, and implication in bioluminescence imaging
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Abstract
A three dimensional (3D) photon transport model has been developed based on the frequency domain simplified spherical harmonics approximation (SPN) to the Radiative Transport Equation. Based on preliminary Monte Carlo studies, it is shown that for problems exhibiting strong absorption, the solutions using the 7th order SPN model (N = 7) are significantly more accurate than those from a standard Diffusion (SP1) based solver. This advance is of particular interest in the field of bioluminescent imaging where the peak emission of light emitting molecular markers are closer to the visible range (500 - 650 nm) corresponding to strong absorption due to hemoglobin.
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M. Chu, M. Chu, A. D. Klose, A. D. Klose, I. B. Styles, I. B. Styles, K. Vishwanath, K. Vishwanath, H. Dehghani, H. Dehghani, } "Frequency domain 3D simplified spherical harmonics approximation: development, validation, and implication in bioluminescence imaging", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 717422 (23 February 2009); doi: 10.1117/12.808756; https://doi.org/10.1117/12.808756
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