Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using OCT

Christopher G. Rylander; Thomas E Milner

doi:10.1117/12.821204

24 February 2009 Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using OCT

Christopher G. Rylander, Thomas E Milner

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Proceedings Volume 7175, Optical Interactions with Tissue and Cells XX; 71750C (2009) https://doi.org/10.1117/12.821204
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We report results of a study to evaluate effectiveness of a mechanical tissue optical clearing device (TOCD) using optical coherence tomography (OCT). The TOCD consists of a pin array and vacuum pressure source applied directly to the skin surface. OCT images (850 and 1310 nm) of in vivo human skin indicate an increased light penetration depth (enhanced approximately 2 fold over peripheral tissue) which spatially correlates with TOCD pin indentations. Increased contrast of the epidermal-dermal junction in OCT images spatially correlates with indented zones. OCT M-scans (time sequence of depth scans) indicate optical penetration depth monotonically increased throughout the entire image acquisition period with most improvement at early times of TOCD application with vacuum. Results of our study suggest that mechanical optical clearing of skin may provide a means to deliver increased light fluence to dermal and subdermal regions.

Citation Download Citation

Christopher G. Rylander and Thomas E Milner "Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using OCT", Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 71750C (24 February 2009); https://doi.org/10.1117/12.821204

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KEYWORDS

Tissue optics

Optical coherence tomography

Skin

Light scattering

Scattering

Optical clearing

Prototyping

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