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12 February 2009 The generation of the synchronized burst in the cultured neuronal networks
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The spontaneous synchronous activity is a common behavior in a developing brain and plays a critical role in establishing appropriate connections and certain clinical diseases. Therefore, the investigation of the synchronous firing is important for understanding the formation of functional circuits and their implications in the network plasticity. In a limited period of time during development, the neuronal networks show synchronous activities, which occur simultaneously on a large amount of cells and varies wildly among different preparations. In this study, the spontaneous synchronous bursts are observed during the development of cultured neuron networks on multi-electrode array. The initiating site of a round of spontaneous synchronous burst, estimated from the relative delays of onsets of activities between electrodes, distributed randomly from each burst, while our statistical results confirmed that the positions of such initiating sites are stable. By calculating the cross-correlation function of the spike trains recorded from different electrodes simultaneously, the spreading mode and the spreading topography of the synchronized bursting activity were described. To access the changes in firing patterns in disinhibited cultured networks, the spontaneous activities were compared with the firings when the network exposed to bicuculline, the blocker of GABAA receptor. The results showed that the generation of synchronous bursts in cultured neuron networks is governed by the level of spontaneous activities and by the balance between excitation and inhibition circuits.
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Xiangning Li, Jing Sun, Wenjuan Chen, Shaoqun Zeng, and Qingming Luo "The generation of the synchronized burst in the cultured neuronal networks", Proc. SPIE 7176, Dynamics and Fluctuations in Biomedical Photonics VI, 71760H (12 February 2009);

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