Numerous publications have qualitatively indicated that the optical clearing technique by using biocompatible
hyperosmotic agents could reduce the scattering effects within
bio-tissue and further enhance the light to penetrate into it.
However, few investigations have been carried out to quantitatively describe this effect and put it in use. In this talk, the
permeation courses of biocompatible hyperosmotic agents into porcine skin tissue were simplified. A skin diffusion
optical model was built to dynamically describe the courses of biocompatible hyperosmotic agents penetrating into skin,
which was affected by the osmotic diffusivity of the model, and the changes of skin optical properties during the
permeation courses. Meanwhile, experiments and skin Monte Carlo(MC) simulation studies were performed to
investigate the optical clearing of porcine skin tissues medicated without and with biocompatible hyperosmotic agents.
Both experimental and MC simulation results showed the availability of the diffusion model, which could quantitatively
describe the change degree of optical property parameters with hyperosmotic agents immersing into different layers of
skin. Therefore, the skin optical diffusion model would be potentially used to investigate how to quantitatively control
the change of the optical property parameters of skin tissue topically applied with biocompatible hyperosmotic agents.
Keywords: optical clearing, skin diffusion optical model, optical properties, Monte Carlo simulation, skin tissue