12 February 2009 Reflection mode photoacoustic imaging through infant skull toward noninvasive imaging of neonatal brains
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Abstract
The feasibility of transcranial imaging of neonatal brains with reflection mode photoacoustic technology has been explored. By using unembalmed infant skulls and fresh canine brains, experiments have been conducted to examine the ultrasound and light attenuation in the skull bone as well as consequent photoacoustic images through the skull. Mapping of blood vessels in a transcranial manner has been successfully achieved by employing the raster scan of a single-element transducer or a 2D PVDF array transducer. Experimental results indicate that noninvasive photoacoustic imaging of neonatal brain with a depth of 2 cm or more beneath the skull is feasible when working with near-infrared light. This study suggests that the emerging photoacoustic technology may become a powerful tool in the future for noninvasive diagnosis, monitoring and prognosis of disorders in prenatal or neonatal brains.
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Xueding Wang, Xueding Wang, J. Brian Fowlkes, J. Brian Fowlkes, David L. Chamberland, David L. Chamberland, Guohua Xi, Guohua Xi, Paul L. Carson, Paul L. Carson, } "Reflection mode photoacoustic imaging through infant skull toward noninvasive imaging of neonatal brains", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 717709 (12 February 2009); doi: 10.1117/12.806651; https://doi.org/10.1117/12.806651
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