In vivo noninvasive monitoring of microhemodynamics using optical-resolution photoacoustic microscopy

Song Hu; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/12.809297

24 February 2009 In vivo noninvasive monitoring of microhemodynamics using optical-resolution photoacoustic microscopy

Song Hu, Konstantin I. Maslov, Lihong V. Wang

Proceedings Volume 7177, Photons Plus Ultrasound: Imaging and Sensing 2009; 71770H (2009) https://doi.org/10.1117/12.809297
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Microvascular autoregulation is an intrinsic ability of vascular beds to compensate for the fluctuation in blood flow and tissue oxygen delivery. This function is crucial to maintaining the local metabolic activity. Here, using optical-resolution photoacoustic microscopy (OR-PAM), we clearly observed vasomotion and vasodilation in the intact mouse microcirculation in vivo in response to the changes in physiological state. Our results show that a significant lowfrequency vasomotion can be seen under hyperoxia but not hypoxia. Moreover, significant vasodilation is observed when the animal status is switched from hyperoxia to hypoxia. Our data show that arterioles have more pronounced vasodilation than venules.

Citation Download Citation

Song Hu, Konstantin I. Maslov, and Lihong V. Wang "In vivo noninvasive monitoring of microhemodynamics using optical-resolution photoacoustic microscopy", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770H (24 February 2009); https://doi.org/10.1117/12.809297

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KEYWORDS

In vivo imaging

Hypoxia

Photoacoustic microscopy

Tissue optics

Hyperoxia

Oxygen

Tissues

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