12 February 2009 Three-dimensional photoacoustic tomography of small animal brain with a curved array transducer
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We present the application of an optimized curved array photoacoustic tomographic imaging system, which can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system can produce a B-mode, 90-degree field-of-view image at sub-200 μm resolution at a frame rate of ~1 frame/second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-degree scan can be achieved within 15 seconds. In previous work, two-dimensional ex vivo mouse brain cortex imaging has been reported. In the current work, we report three-dimensional small animal brain imaging obtained with the curved array system. The results are presented as a series of two-dimensional cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Finally, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2D imaging.
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Xinmai Yang, Xinmai Yang, Lihong V. Wang, Lihong V. Wang, Anastasios Maurudis, Anastasios Maurudis, John Gamelin, John Gamelin, Andres Aguirre, Andres Aguirre, Quing Zhu, Quing Zhu, } "Three-dimensional photoacoustic tomography of small animal brain with a curved array transducer", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770K (12 February 2009); doi: 10.1117/12.809590; https://doi.org/10.1117/12.809590

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