24 February 2009 Endoscopic photoacoustic microscopy
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We present a concept and system implementation for endoscopic photoacoustic microscopy that enables minimally invasive diagnosis of internal organs. The system incorporates an in-house made single element ultrasonic transducer for photoacoustic signal detection and an optical fiber for light delivery into a tubular probe with a mechanical scanning unit. The implemented probe size for the distal end is 4.2 mm in diameter and 48 mm in length. We evaluated the system's performance by imaging a carbon fiber in clear and turbid media. We also demonstrated its ability to image actual biological tissues and its endoscopic applicability, by imaging abdominal surfaces and a large intestinal tract of a rat ex vivo. This study shows the system's potential for in vivo optical biopsy of tissue abnormalities, such as tumors, developed in internal organs.
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Joon-Mo Yang, Konstantin Maslov, Hao-Chung Yang, Qifa Zhou, Lihong V. Wang, "Endoscopic photoacoustic microscopy", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770N (24 February 2009); doi: 10.1117/12.810952; https://doi.org/10.1117/12.810952

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