12 February 2009 Spectroscopic intravascular photoacoustic imaging of neovasculature: phantom studies
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An acceleration of angiogenesis in the adventitial vasa-vasorum is usually associated with vulnerable, thin-cap fibroatheroma in atherosclerotic plaques. Angiogenesis creates microvasculature too small to be detected and differentiated using conventional imaging techniques. However, by using spectroscopic photoacoustic imaging, we take advantage of the wavelength-dependent optical absorption properties of blood. We used a vessel-mimicking phantom with micro blood vessels. The phantom was imaged with intravascular photoacoustic imaging across a range of wavelengths. The image intensities were cross-correlated with the known absorption spectra of blood. The resulting cross-correlation image was able to reveal the location of the artificial blood vessels differentiated from non-blood vessel components.
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Jimmy L. Su, Jimmy L. Su, Bo Wang, Bo Wang, Stanislav Y. Emelianov, Stanislav Y. Emelianov, } "Spectroscopic intravascular photoacoustic imaging of neovasculature: phantom studies", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 717727 (12 February 2009); doi: 10.1117/12.807499; https://doi.org/10.1117/12.807499

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