24 February 2009 Cell viability studies of PEG-thiol treated gold nanorods as optoacoustic contrast agents
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Abstract
Rod shaped gold nanoparticles are synthesized using cetyltriammonium bromide (CTAB) as a major component of growth solutions. This surfactant is toxic to cells, but is at the moment unavoidable when monodisperse and high yield nanorods are to be synthesized. CTAB is found coating side walls of the nanoparticles and plays a role in maintaining colloidal stability. It may be displaced using thiolated PEG which is non-toxic to cells. Here we report on systematic studies of cell viability of such PEGylated nanorods on an SKBR3 cell-line using the MTS assay. These PEGylated particles are characterized using electron microscopy, optical spectroscopy and zeta potential measurements. It is expected that such treatment will be crucial in making nanorods compatible for in vivo biomedical applications.
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Srirang Manohar, Srirang Manohar, Rajagopal Rayavarapu, Rajagopal Rayavarapu, Wilma Petersen, Wilma Petersen, Ton G. van Leeuwen, Ton G. van Leeuwen, } "Cell viability studies of PEG-thiol treated gold nanorods as optoacoustic contrast agents", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71772D (24 February 2009); doi: 10.1117/12.808547; https://doi.org/10.1117/12.808547
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