Reactive oxygen species (ROS) is not a promotor of taxol-induced cytoplasmic vacuolization

Qingrui Sun; Tongsheng Chen

doi:10.1117/12.807256

25 February 2009 Reactive oxygen species (ROS) is not a promotor of taxol-induced cytoplasmic vacuolization

Qingrui Sun, Tongsheng Chen

Proceedings Volume 7178, Biophotonics and Immune Responses IV; 71780K (2009) https://doi.org/10.1117/12.807256
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

we have previously reported that taxol, a potent anticancer agent, induces caspase-independent cell death and cytoplasmic vacuolization in human lung adenocarcinoma (ASTC-a-1) cells. However, the mechanisms of taxol-induced cytoplasmic vacuolization are poorly understood. Reactive oxygen species (ROS) has been reported to be involved in the taxol-induced cell death. Here, we employed confocal fluorescence microscopy imaging to explore the role of ROS in taxol-induced cytoplasmic vacuolization. We found that ROS inhibition by addition of N-acetycysteine (NAC), a total ROS scavenger, did not suppress these vacuolization but instead increased vacuolization. Take together, our results showed that ROS is not a promotor of the taxol-induced cytoplasmic vacuolization.

Citation Download Citation

Qingrui Sun and Tongsheng Chen "Reactive oxygen species (ROS) is not a promotor of taxol-induced cytoplasmic vacuolization", Proc. SPIE 7178, Biophotonics and Immune Responses IV, 71780K (25 February 2009); https://doi.org/10.1117/12.807256

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