12 February 2009 Effect of PDT-treated apoptotic cells on macrophages
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Abstract
Recently, the long-term immunological effects of photodynamic therapy have attracted much attention. PDT induced immune response was mainly initiated through necrotic cells and apoptotic cells, as well as immune cells such as macrophages. Nitric oxide (NO) as an important regulatory factor in signal transfer between cells has been wildly studied for generation, development, and metastasis of tumors. NO synthase is a key enzyme in nitric oxide synthesis. However, inducible nitric oxide synthase (iNOS) is usually activated under pathological conditions, such as stress and cancer, which can produce high levels of nitric oxide and contribute to tumor cytotoxicity. In addition, increased NO production by iNOS has been associated with the host immune response and cell apoptosis, which play an important role in many carcinogenesis and anti-carcinoma mechanisms. This study focuses on the NO production in macrophages, induced by mouse breast carcinoma apoptotic cells treated by PDT in vitro, and on the effects of immune response induced by apoptotic cells in tumor cells growth.
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Sheng Song, Da Xing, Fei-fan Zhou, Wei R. Chen, "Effect of PDT-treated apoptotic cells on macrophages", Proc. SPIE 7178, Biophotonics and Immune Responses IV, 71780O (12 February 2009); doi: 10.1117/12.808625; https://doi.org/10.1117/12.808625
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