The basic unit of life and death is the cell. The two main modes of cell death, cell death with necrosis and apoptosis, are
characterized by relatively easily recognizable, different morphologic changes before, during and after the cell has died.
However, more recent advanced investigations of the physiologic, biochemical and genetic aspects of cell death have
produced a wealth of information. But, the final analysis of this embarrassment of riches awaits the accumulation of
more knowledge and understanding of how all the pieces fit together and relate to each other. Currently, the analyses are
complicated by the isolated and narrow scope of the experimental subjects, a lack of uniformity of nomenclature and
missing information that would allow successful understanding of the "big picture." Some causes and mechanisms of
heat-induced cellular and tissue death will be considered from anatomical, pathological, physiological, biochemical and